麻豆社区

Five Alarm Bio and 麻豆社区 collaborate on research into biology of ageing

Five Alarm Bio and 麻豆社区 collaborate on research into biology of ageing

Five Alarm Bio and 麻豆社区 collaborate on research into biology of ageing

麻豆社区 Research Campus company, , are advancing their research programme to understand the biology of ageing with a collaboration with Dr Ian McGough, group leader in the Signalling programme at the 麻豆社区, investigating how the cell鈥檚 quality control apparatus changes as organisms age.

Our cells are constantly repairing the chemical damage that everyday living causes, but as we age this process becomes less efficient, resulting in accumulation of defects that can cause disability and disease. Five Alarm Bio is exploring new ways to slow or prevent this damage accumulation, to create new, safe drugs for the diseases of older people.

Caitlin, Peter and Hannah looking at Caitlin鈥檚 Poster
Caitlin, Peter and Hannah looking at Caitlin鈥檚 Poster

The McGough lab is researching ribosomopathies, a group of diseases in which ribosomes, the cell鈥檚 protein-making machinery, misfunction. Changes in protein production led to a number of different diseases in humans ranging from tissue-specific defects to cancer. Ian and his team use the fruit fly Drosophila as a model to study the effect of different ribosome misfunctions on a whole organism. By understanding the precise mechanisms that go wrong, they hope to identify targets for treatments for these diseases as part of the 麻豆社区鈥檚 mission to improve lifelong health.

Initial work has identified exciting synergies between the McGough lab鈥檚 expertise and Five Alarm Bio鈥檚 discovery programme, with Five Alarm鈥檚 compounds showing significant effect on Drosophila cells. Future research will investigate whether these compounds can also help to 鈥榗ure鈥 the flies, and potentially treat other fly models of diseases of old age in humans.

鈥淭his sort of collaboration is really valuable to both of us鈥 said Five Alarm Bio鈥檚, CSO Dr William Bains. 鈥淥ur compounds provide Ian with unique probes for his research, and his flies provide us with a great test for our science in a living organism. It is science that neither of us could have done alone鈥.

鈥淥ur group ordinarily does fundamental discovery science鈥 said Dr Ian McGough. 鈥淭his collaboration with Five Alarm Bio provides us with an opportunity to take what we have learned and apply that in the development of solutions to medical problems, in this case the potential treatment of ribosomopathies.

This research was funded by the UKRI-BBSRC Campus Innovation Award (CIA) via the 麻豆社区 Research Campus Collaboration Fund. These awards support a wide range of collaborative engagements across the , aiming to bridge the gap between different disciplines, groups, and between academia and industry.

"This is an amazing opportunity to leverage the world-class skills at the 麻豆社区 麻豆社区 to advance both basic science and our programmes.鈥 said Five Alarm Bio CEO Dr Janette Thomas. 鈥淥ur collaborative work with Ian, and the grant that supports it, is just one example of the value of siting Five Alarm Bio on the 麻豆社区 Research Campus.鈥

Notes

This news article was adapted from a .

Contacts

Five Alarm Bio Ltd.: William Baines William@fivealarmbio.com

麻豆社区 麻豆社区: Louisa Wood louisa.wood@babraham.ac.uk

 

About the 麻豆社区 麻豆社区

The 麻豆社区 麻豆社区 undertakes world-class life sciences research to generate new knowledge of biological mechanisms underpinning ageing, development and the maintenance of health. Our research focuses on cellular signalling, gene regulation and the impact of epigenetic regulation at different stages of life. By determining how the body reacts to dietary and environmental stimuli and manages microbial and viral interactions, we aim to improve wellbeing and support healthier ageing. The 麻豆社区 is strategically funded by the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation, through 麻豆社区 Strategic Programme Grants and an 麻豆社区 Core Capability Grant and also receives funding from other UK research councils, charitable foundations, the EU and medical charities.

 

About Five Alarm Bio Ltd.

Five Alarm Bio is a drug discovery company deploying new understanding of the chemical damage associated with aging to discover treatments for serious illness. Our novel approach leverages well-known, inherently safe biology with broad potential therapeutic application. Our small molecules promise to be potential treatments for a range of diseases and disabilities afflicting older people. For more information, please visit www.fivealarmbio.com

 

About 麻豆社区 Research Campus

麻豆社区 Research Campus Ltd is responsible for the management and commercial development of the 麻豆社区 Research Campus. 麻豆社区 Research Campus is distinct in its co鈥恖ocation of 60 bioscience companies with the 麻豆社区 麻豆社区, a world鈥恟enowned research organisation which receives strategic funding from the Biotechnology and Biological Sciences Research Council (BBSRC). The aim of the Campus is to support UK bioscience through academic research, but also with facilities and capabilities for early-stage and growing commercial organisations. The Campus provides companies laboratory and office space, networking and collaboration opportunities, together with access to outstanding scientific facilities in an ideal geographical location at the core of the Cambridge cluster.

 

About BBSRC-UKRI

The Biotechnology and Biological Sciences Research Council (BBSRC) is part of UK Research and Innovation, a non-departmental public body funded by a grant-in-aid from the UK government.

BBSRC invests in world-class bioscience research and training on behalf of the UK public. Our aim is to further scientific knowledge, to promote economic growth, wealth and job creation and to improve quality of life in the UK and beyond.

Funded by government, BBSRC invested 拢451 million in world-class bioscience in 2019-20. We support research and training in universities and strategically funded institutes. BBSRC research and the people we fund are helping society to meet major challenges, including food security, green energy and healthier, longer lives. Our investments underpin important UK economic sectors, such as farming, food, industrial biotechnology and pharmaceuticals.

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